Release date: 2007-03-22
Advances in research on anti-depression of traditional Chinese medicine
At present, the clinical treatment of depression mainly relies on chemical synthetic drugs. Many patients are often forced to stop treatment because of the serious side effects of taking these drugs for a long time. Therefore, the search for and development of ideal antidepressants from natural and traditional Chinese medicines has attracted the attention of researchers. In recent years, domestic and foreign scholars have made gratifying progress in related research in the field of traditional Chinese medicine.
Single-flavored Chinese medicine has found more single-flavored Chinese herbal medicines with antidepressant effects, and some herbs have been developed. At present, the single-flavor Chinese medicine with more research is Bayu Tian. For example, Zhang Zhongqi of the Institute of Pharmacology and Toxicology of the Academy of Military Medical Sciences found that in the low-rate differential intensification model of rats, the effect of the extract of Morinda officinalis was consistent with that of the antidepressant desipramine; in the forced swimming experiment in mice The effect of the extract of Morinda officinalis was similar to that of desipramine and amitriptyline, indicating that the extract of Morinda officinalis has antidepressant activity. The same method studies have shown that the ethanol extract of Morinda officinalis also has antidepressant effects.
Experiments conducted by Xu Jinghua of the School of Pharmacy of Shenyang Pharmaceutical University showed that the extract of Hypericum perforatum 150 mg/kg and 300 mg/kg significantly shortened the immobility time of forced swimming mice and tail suspension mice, and significantly antagonized reserpine The effect of hypothermia and the drooping effect of the eyelids in mice; Li Mingya et al. from the Guangdong College of Pharmacy reported that the decoction of Shichangpu can significantly shorten the disappointment time of mouse tail suspension and the immobility time of rat forced swimming test. A certain dose-dependent, but its pharmacological effects are weaker than fluoxetine; Chen Yao, from the Second Military Medical University of the People's Liberation Army, studied the antidepressant effect of Centella asiatica extract and found that in the forced swimming test of rats, snow The herb extract and intraperitoneal injection reduced the immobility time of forced swimming in rats to varying degrees. The effect of intragastric administration was better than that of intraperitoneal injection, showing a good dose-dependent relationship, and the extract of Centella asiatica was high. The dose group was similar to imipramine.
In addition, dozens of traditional Chinese medicines such as betel nut, Bupleurum, Shichangpu and Astragalus have also been shown to have antidepressant effects.
The prescription Chinese herbal compound has great potential in the treatment of depression. The classic prescriptions such as Ganmai Dazao Decoction, Banxia Houpu Decoction, Oyster Soup and Lily Dihuang Decoction all show antidepressant activity. Wu Jianming of Wannan Medical College made a study on the antidepressant effect of Jiawei Ganmai Dazao Decoction. He evaluated the HAMD-17, CGI-SI scale and clinical efficacy of 54 patients who met the diagnostic criteria for depression. Jujube soup has a positive effect, the effective rate is 67.9%, and the efficiencies of fluoxetine 65.4% are similar. There is no significant difference between the two groups (P>0.05). In the incidence of adverse reactions, the sweetened Ganmai jujube soup was significantly less than fluoxetine, indicating that the sweetened Ganmai jujube soup is a safe and effective antidepressant for traditional Chinese medicine. The forced swimming test in mice also showed that Ganmai Dazao Tang has antidepressant effects.
Zhang Youzhi of the School of Basic Medicine of Beijing University of Traditional Chinese Medicine observed the effects of Chaihu plus keel oyster soup, Lily Dihuang Decoction and Ganmai Dazao Decoction on the immobility time in mice forced swimming test. On this basis, chronic A behavioral study of Bupleurum and keel oyster soup was carried out in a rat model. The mice forced swimming test showed that Chaihu plus keel oyster soup, Ganmai jujube soup, Lily Dihuang soup and Other prescriptions have antidepressant effects, of which Chaihu plus keel oyster soup is more significant, chronic stress rats The model further demonstrates the antidepressant effect of Chaihu plus keel oyster soup.
Meng Haibin of China Pharmaceutical University used mouse forced swimming test, tail suspension, 5-hydroxytryptophan (5-HTP) to induce taro and other depression models. It was observed that Chaihu plus keel oyster soup can shorten the forced swimming and suspension of mice. The desperate behavior of the animals in the tailless time and the hanging tail model indicates that the Chaihu plus keel oyster soup has antidepressant effects. In 5-HTP-induced taro behavior, Chaihu plus keel oyster soup can significantly increase the 5-HTP-induced taro behavior, and its antidepressant effect and the weight of monoamine neurotransmitters such as central 5-hydroxytryptamine (5-HT) Ingestion related.
Fu Qiang of China Pharmaceutical University used experimental animal models such as forced swimming test, tail suspension and yohimbine enhancement to evaluate the antidepressant effect of Banxia Houpu Decoction. It was found that Banxia Houpu Decoction can significantly shorten the forced swimming and suspension of mice. The tail does not move, indicating that Banxia Houpu Decoction has obvious anti-depressant activity. Li Jianmei from the College of Life Sciences of Nanjing University studied the effects of the ethanol extract of Banxia Houpu Decoction on the chronic depression model (CMS) in rats and explored its antidepressant mechanism. The results showed that in the rat CMS model, the alcohol extract of Banxia Houpu soup can increase the sucrose intake of the animal; it can achieve antidepressant purpose by changing the abnormal biochemical indicators under depression.
In addition, Banxia Houpu Tang, Xiaoyao San and Dan Xiaoyao San have also been confirmed to have antidepressant effects.
Source: China Medical News
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