Release date: 2018-03-01
The relevant research results are published in "Nature-Neurology" under the title "Repopulated microglia are randomly derived from the proliferation of residual microglia after acute depletion".
The regenerative capacity of the adult mammalian central nervous system (including the brain, retina, and spinal cord) is extremely limited, and it has been considered for a long time that the damage to the central nervous system will not be repaired. In 2014, researchers at the University of California, Irvine, discovered cell regeneration in the brain of mice and found that the brain can be almost completely killed by specifically inhibiting the colony-stimulating factor 1 receptor (CSF1R). Within the microglia (>99%); when the inhibition is stopped and after a short recovery period, newborn microglia appear in the brain. These regenerated microglia can colonize the whole brain quickly and return to their original state (such as density, distribution and morphology) in a week or so. This is the first large-scale cell regeneration phenomenon found in the central nervous system of adult mammals. This process is called "microglia repopulation." The University of California team speculated by histological immunostaining that repopulated microglia might be differentiated from a class of cells that transiently express Nestin in the brain. This is considered to be a third type of stem cell found in the central nervous system of adult mammals, in addition to neural stem cells and oligodendrocyte precursor cells. The conclusion has received widespread attention once published, and it has also brought great controversy.
In the study, the Peng Bo team and others overturned the conclusion that the repopulation microglia originated from Nestin-positive precursor cells through a cleverly designed multiple lineage tracking technique, and found that the repopulated microglia completely originated from the brain. Less than 1% of microglia remaining in the body self-proliferate. This phenomenon is the fastest cell proliferation phenomenon found so far in the adult mammalian central nervous system. In addition, the Peng Bo team also explained the possible mechanism of cell re-colonization by single-cell RNA sequencing technology, and found that the repopulation microglia and the primary microglia are highly similar in function by whole brain RNA sequencing. Sex. For the first time, the study systematically illustrates the origin of repopulation microglia through a rigorous multi-lineage tracing technique, ending the major controversy over the presence of microglial precursor cells in the adult mammalian central nervous system, to the central nervous system. Systematic regeneration studies and the maintenance of microglia homeostasis have significant scientific value.
Peng Bo team postdoctoral Huang Yubin and Xu Wei are the co-first authors of the paper. The research was funded by the National Key Research and Development Program, the National Natural Science Foundation, the Shenzhen Knowledge Innovation Program, the Guangdong Innovation Team, and the Shenzhen Peacock Team.
Paper link:
Https://
The origin of repopulation of microglia in the brain
Source: Shenzhen Advanced Technology Research Institute
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