Nanorods interrupt the "legs" of cancer cells: successful inhibition of cancer spread

"Your cancer has been transferred, sorry," no one wants to hear from the doctor.

The most common form of cancer cells is to leave the original tumor by crawling and re-implant the important parts of the body during the transfer process. Now, a research team led by the Georgia Institute of Technology has developed a new treatment, in a sense, to break the legs of cancer cells.

Cancer cells often cover their long leg-like projections, allowing them to creep. According to a new study, researchers have used tiny gold rods that are gently heated by a laser to smash the protrusions. In experiments in which laboratory cells (in vitro) of cancer cells are cultured, this treatment prevents cell migration (a mechanism that leads to metastasis).

This approach may potentially provide clinicians with individual tumors in the future as a weapon against both the lethal spread of cancer. The medical field is currently not enough to stop the transfer.

纳米棒打断癌细胞的“腿”:成功抑制癌症扩散

Chief researcher Mostafa El-Sayed said: "If cancer stays in a tumor in one place, you can catch it and it is unlikely to kill the patient, but it really kills it when it spreads around the body.

Treatment can also easily kill cancer cells, but in this experiment it is important to show that cell migration is largely indicated.

Gently stop the cancer

In these experiments, experimental treatments also eliminated healthy cells in previous experiments, making the method pay much less to patients than conventional chemotherapy. In past animal model tests, researchers have found that gold bars used in treatment have no toxic side effects and that low-energy lasers have no observable damage to healthy tissue.

They did not see a recurrence of cancer treatment.

El-Sayed said: "This method seems to be very effective. As a treatment for topical administration, it can also protect the body from cancer spread away from the treated tumor, and it is also very mild, so it can be administered multiple times if needed.

Co-editor Wu Ronghu, the first author Yue Wu and Masafa Ali Ali published their current in vitro results, which is a new development in the treatment of photothermal gold nanorods, which was announced on June 26, 2017 in the National Assembly. The study was funded by the National Science Foundation and the National Institutes of Health.

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