Cardiovascular disease has been called the "number one killer" in the field of diseases. According to the "China Cardiovascular Disease Report 2016", cardiovascular deaths account for the first cause of total deaths in urban and rural residents. According to projections, cardiovascular diseases are now sick. With a population of about 290 million, it is in a period of rapid growth and high incidence of chronic diseases. In the next 10 years, the development potential of cardiovascular therapy is huge.
In addition to the hospital's diagnosis and treatment, pre-hospital screening and prevention, as well as post-hospital follow-up and intervention, play a crucial role in controlling the incidence and recurrence rate of cardiovascular disease. Due to the sustainable tracking of the wearable medical device and the convenience of the use of the scene, it is usually used for pre-diagnosis screening and follow-up of the patient after treatment.
According to incomplete statistics, there are more than 70 mainstream wearable ECG monitoring devices in the market, which are mainly wearable and portable, and the functions are also very similar. In the field of many ECG monitoring of competitors, Bodiga How to make differentiated product forms, what is special about their products? Recently, the arterial network reporter interviewed Gao Xiangdong, founder and CEO of Bodija Technology.
From military to medical care , dynamic monitoring of ECG on clothing
Gao Xiangdong, who studied electronic measuring instruments, has been serving the military and aerospace fields. He is also engaged in the localization of high-end electronic measuring instruments. In his words, in the past ten years, he has been "communicating with signals." At the time of the rise of mobile medical in 2014, he realized the niche and closedness of the military industry, so he relied on the foundation of the electronic measuring instrument industry to work with the previous team to target the health management of wearable medical equipment. .
Gao Xiangdong pointed out that at present, the way hospitals use for long-term ECG monitoring is mainly 24-hour Holter monitoring, commonly known as “Houtâ€. The characteristics of this type of equipment are that although they can be used in hospital, their electrophysiological sensors are used. The wet electrode is mainly based on the electrolytic gel between the sensor and the patient's skin to improve the sensor's ability to sense the electrical signal of the body. At the same time, the patient needs to stick 10 or less electrodes on the body and carry the recording box.
Whether it is from the experience of the visit or the experience of use, such products have caused inconvenience to patients to some extent.
Against Healthwatch, Israel's wearable ECG monitoring device, the team thought of making a product that would allow patients to wear it. After two years of research and development, Bodija's electric shirt was officially launched. Although the appearance looks like an ordinary T-shirt, it is essentially a real-time dynamic health monitoring and early warning system for ECG activities. The system can continuously analyze the output signal of the unique flexible sensor embedded in the T-shirt to achieve a long-term heart. Electrical data monitoring.
Bodijia heart electric clothes (for business)
Good products need to be accurate, comfortable, beautiful, and low cost
At present, Bodija's products are divided into two parts. One is the hardware products mainly based on myoelectricity and electrocardiogram. Among them, myoelectric products are mainly used in scientific research, sports rehabilitation, and neurological rehabilitation, while ECG products are mainly used. Screening and follow-up management of cardiovascular chronic diseases; secondly, software based on APP and PC end forms, including cloud platform for monitoring and analyzing ECG data.
For Bodija, the first question is how to make the data accurate. ECG signal monitoring is based on the principle of non-invasive, usually using surface electrodes, and electrodes that do not need to be used with conductive paste are called “dry electrodesâ€. Their impedance, polarization characteristics, stability, etc. have a greater impact on measurement accuracy. Big.
The current biomedical sensor cannot be integrated with clothing, and can not be stretched, and has a poor body feeling. At the same time, its anti-interference ability is weak, which may cause poor contact with the skin during exercise, and the reliability is poor, affecting the biomedical signal. transmission. It is difficult to collect human body data on clothing and it is continuous dynamic ECG data.
Gao Xiangdong told the arterial network reporter: "From the electrical environment, clothing is actually a relatively unclean environment. The fabric friction of the clothing will generate static electricity, static electricity interference, including electrode materials, electrode placement methods, and electrical signal transmission methods. Acquisition has an impact."
In order to solve the above problems, Bodija has strategically cooperated with DuPont, the world's leading chemical company, for two years to develop flexible sensors and flexible sensor modules based on conductive ink printing technology. The module solves the problem of poor contact of the conventional dry electrode and solves the core problem of retractable, bendable and washable. Gao Xiangdong believes that the team's achievement is to develop the "closest to the wet-level accuracy". Electric level". He said: "Under the premise of ensuring the efficacy of the product, 100 times of washing, the life cycle of each smart clothing is about one year."
Flexible sensor for Bodija smart clothing (for business)
Referring to the comparative experiment of YY1079-2008 ECG monitor, Bodijia smart clothing reached 99.7%, 99.8% and 96. respectively in QRS wave detection sensitivity, QRS wave detection positive prediction sensitivity and PVC positive prediction degree. 5% accuracy.
After realizing the accuracy of the data, considering the form of the clothing, the two problems facing Gao Xiangdong are comfortable and beautiful. In his opinion, Bodija’s products, “can’t be like Holter, when going out With a 'big box', the user is labeled with the patient." It should be a vest that looks ordinary but can protect the heart, and it is also our "armor".
In materials and built-in smart hardware, Bodija's heart-coats are mainly made of nylon and Lycra fabrics, and are equipped with the world's smallest, lightweight 7.8g high-precision ECG, respiratory signal acquisition, storage and transmission system. Realize the collection and recording of ECG data for 24 hours.
High-precision ECG, respiratory signal acquisition, storage and transmission system (for business)
In terms of cost, although there are technical difficulties, whether or not to have automated process production conditions is the key to determining whether the product can ultimately achieve mass production. Gao Xiangdong believes: "This product should not be a 'luxury' and needs to be automated. The process reduces the production cost, the price should be reasonable, and everyone must be able to afford it.†At present, the Bodija heart-shaped electric device with the sensor has reached the same price as the ordinary clothing.
Empowering cardiovascular medicine to improve primary and secondary medical treatment
In the field of application, Bodija focuses on medical care while radiating sports and industrial applications. 2018 is the first year of Bodija's force medical field. But in fact, Bodija has been targeting the medical market since its inception. In terms of medical care, Bodija is mainly for B-end customers, and uses Bodija's electric clothes and other products to empower partners. Through smart clothing to open up the connection between patients and medical institutions, become the entrance to medical and health big data, the tool platform of medical service institutions.
China's famous cardiovascular expert, Academician Zhang Yun of the Chinese Academy of Engineering has pointed out that at present, China's cardiovascular disease treatment field should actively deal with two major problems. First, the number of patients sinking from large hospitals to primary hospitals is huge, and the second is cardiovascular disease. The ability to diagnose and treat at the grassroots level is urgently needed. Faced with 290 million cardiovascular patients in China, the distribution of specialists is extremely uneven. The level of diagnosis and treatment of cardiovascular diseases in various primary hospitals is still uneven. As a result, many models of cardiovascular specialists have emerged throughout the country.
Bodija product application model (for business)
In response to such pain points, Bodija has cooperated with Heart Alliance, Heart Medicine International and other organizations to assist in the remote diagnosis and treatment of cardiovascular diseases, and to provide remote services to enterprises through cloud algorithms to manage data of grassroots patients. Work together with partners to establish a primary hospital to establish atrial fibrillation screening center, and at the same time to build a pre-hospital screening, post-hospital follow-up, long-term monitoring of the diagnosis and treatment system.
Through the intelligent electro-optical clothing and the accompanying APP software, long-term ECG monitoring and event ECG recording can be realized. The patient can be collected and recorded for 24 hours, and an electrocardiogram PDF report can be generated. At the same time, according to the indicators to determine arrhythmia and other events, when the abnormality is detected in the electrocardiogram, the special time event is marked, and the electrocardiogram is recorded 1 min before and after the event. After the data is clouded, the medical institution can view the data and report through the web. Review the situation.
Cooperate with Anzhen Hospital for post-hospital chronic disease management project to monitor abnormal events
In the process of cooperation with medical institutions, Bodija has opened up contacts between patients and primary health care institutions, becoming the entrance to medical and health big data, and the tool platform of medical service organizations. Through a series of solutions, it solves the problem of lack of data collection methods in primary medical care, the ability to interpret data is not strong, and it is impossible to monitor and manage patients, and improve the accuracy of diagnosis and treatment in primary medical institutions. In the remote follow-up, doctors can also manage patients outside the hospital through the platform.
Gao Xiangdong emphasized that Bodija plays the role of data collector in the system of the medical association. “Before the hospital is the screen, the back of the hospital is the tube. In these two links, the data serves as a bridge for turnover. The challenge lies in how Let users be willing to generate this data, and the data is accurate."
Gao Xiangdong believes that the team has always been dealing with signals, mainly electronic engineers, and has extensive experience in signal processing and analysis. Therefore, the professionalism of medical treatment depends on the cooperation with doctors and expert teams such as Heart Alliance and Anzhen Hospital. The development of the whole product, the professionalism and the verification of the use, there are a large number of professional medical expert teams that we cooperate with. input of.
In addition, the significance of working with a team of medical experts is that in the process of R&D and production, the product is adjusted accordingly according to the clinical needs of the doctor. The doctor will help Bodija to continuously verify the requirements during the R&D process and become the product. Trial and mentor.
Gao Xiangdong told the arterial network reporter: "From the beginning, Bodija products began to be made from the needs of doctors. In the process of research and development, doctors in the stage to verify for us, polish products, and finally, when the products are available, The products we make are the products that doctors want.
Exploring multiple business paths by using doctors to annotate ECG data iterative artificial intelligence algorithms
According to Gao Xiangdong, in addition to using traditional sensors to achieve ECG monitoring, the company also cooperates with research universities to develop artificial intelligence technology. High-quality data is the premise and basis of artificial intelligence diagnosis. The quality of data is crucial for the accuracy of diagnosis. He said: "80% of the time in artificial intelligence data processing is doing data pre-processing, the accuracy of labeling Regarding the accuracy of the results."
Therefore, in terms of data acquisition, Bodija chose to cooperate with the doctor group to obtain a large number of high-quality labeled medical case samples, complete the iteration of the algorithm, and obtain a more accurate data model. "In the cloud, we cooperate with some medical associations. A large amount of data is generated and required to be labeled and approved by doctors. The labeled data is iterated continuously, and artificial intelligence algorithms will become more and more accurate." In the words of Gao Xiangdong, artificial intelligence It is another fulcrum of Bodega.
Before providing the division of algorithm services, Bodiga's main business model is to sell product equipment. In addition, based on ECG data collection, it provides users with physical data analysis and collaboration with organizations to realize online consultation for users. Multi-scene services such as medical diagnosis are realized.
At present, Bodija has received three rounds of financing from several intellectuals, Kunshan underwear technology and other institutions, with financing amounting to tens of millions. In the future, Bodija will also use smart devices to perform high-frequency, continuous acquisition and analysis of vital signs, and provide data for medical research and insurance control.
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