Release date: 2016-01-28
The study created a novel photoacoustic/fluorescent multimodal guided diagnostic strategy in response to complex tumor tissue microenvironments and successfully enriched functionalized rare earth upconverting nanoparticles specifically in tumor sites in living animals. To achieve accurate targeted treatment. Under the action of high expression of cathepsin in tumor tissues, the functional polypeptide on the surface of the nanostructure is selectively cleaved, and the exposed amino acid residues and the specific recognition molecules on the surface of adjacent particles undergo a covalent cross-linking reaction, thereby promoting the nanometer. The structure is effectively enriched at the tumor site. The experimental results show that this strategy can not only selectively enrich the rare earth upconverting nanoparticles in the tumor site, but also increase the luminous efficiency of the crosslinked rare earth upconverting nanoparticles under the near infrared laser (808 nm) irradiation. Thereby, the active oxygen generated by the photosensitizer supported on the surface of the nanostructure can be further improved. More importantly, under the guidance of targeting groups, the integrated probe for diagnosis and treatment can significantly enhance the anti-tumor treatment effect in both in situ and intravenous treatment of small animal tumor models, and can simultaneously achieve The real-time non-invasive efficacy monitoring of photoacoustic imaging shows that this strategy has great application potential in the targeted diagnosis and treatment of tumors under the guidance of images.
The research work benefited from the sincere cooperation of many research teams, and was greatly assisted by Professor Chen Xiaoyuan from the American Institute of Health, Professor Gao Mingyuan from Suzhou University, and Professor Chen Huabing. The research work was funded by the Nanyang Technological University Startup Fund of Singapore, the 973 Project of the Ministry of Science and Technology, the National Youth Science Foundation Outstanding Youth Fund, and the New Century Talents Program of the Ministry of Education.
Source: Science Network
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