Skin patch penetration method makes it sick without taking injections
January 22, 2019 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Scientists in Russia and Australia have developed a new method of drug use that attaches a patch with a microneedle to the surface of the skin to deliver the drug into the body. This method can not only improve the use of drugs, but also solve the inconvenience and pain caused by oral tablets and injecting drugs.
Delivering drugs through skin penetration is undoubtedly a promising direction. The researchers found that the outermost stratum corneum of the skin blocks the entry of toxic substances into the body, so only low molecular weight substances can pass through it. To solve this problem, experts have proposed using patches with miniature needles. The principle of this mode of administration is that after a patch with a half-millimeter long microneedle is applied to the skin, the drug contained in the nanocapsule (particle size: 10 μm) is delivered to the human body, and the extracellular fluid gradually becomes an effective substance. Blood flow is introduced from the subcutaneous layer. The outer shell of the nanocapsules is opened for a period of time so that the drug can be slowly absorbed by the body, the patient does not feel pain, and does not need to inject multiple times a day.
It is reported that researchers have been developing interferon-based immunomodulation patches for the treatment of tumors and viral hepatitis. Currently, transdermal drug delivery is about to be preclinical testing in animals.
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