1. Antimicrobial effect: In vitro test 1:4 aqueous extract has various degrees of inhibitory effect on various pathogenic fungi such as Trichophyton mentagrophytes, Trichophyton mentagrophytes, and Brassica chinensis, but there are reports The ethyl ether, ethanol and water extracts of the product had no effect on golden yellow and white cocci, E. coli P. aeruginosa and mycobacterium phlei. 1:20 decoction does not kill Trichomonas vaginalis.
2. Effects on the cardiovascular system and blood: When the amount of betelbine contained in this product has a stimulatory effect on isolated frog hearts in a small amount, myocardial tension can be increased, and both the minute output and the volume of eduction can be increased. There is a clear contraction effect on isolated rabbit ear blood vessels. The anti-arrhythmia effect of Zanthocyanine is contained, ephedrine-like effects of bacteriocin, which can increase the blood pressure of anesthetized cats, enhance the contraction of cat's nictitating membrane, expand the coronary artery, and increase the boosting effect of epinephrine.
3. Effects on the uterus and intestinal smooth muscle: Berberine has a strong contraction effect on uterine smooth muscle in rabbits and guinea pigs. Yininine can also strengthen the uterus contraction in cats or rabbits, and strengthen the effect of epinephrine on the uterus. There was no effect of Yajiaojing on the spontaneous contraction of the rat uterus, but the uterine contraction caused by oxytocin was attenuated, and the vasospasm was increased. Yinchun can inhibit small intestine contraction, Yajiao alkali can inhibit the diarrhea caused by strontium chloride in vitro rabbit ileum, Yajiao base and alkali base can also relax Oddi's sphincter, a report pointed out that dipstick, cliff base Mixtures of scopolamine and the like have stronger antispasmodic effects on rats and guinea pigs than single alkaloids.
4. Anti-cancer effect: Eosin staining results show that the product non-polar solvent extracts and volatile oil have anti-cancer activity in vitro, from the ethyl ether extract of this product was isolated quercetin, diterpenoids and a non-volatile oil derived from The transparent liquid is an effective anti-cancer agent in vitro, and its concentration of 45% can kill Ehrlich ascites carcinoma, S180 and U14 cells, while the flavonoids, limonin, and β-sitosterol are ineffective.
5. Dictamnus albus L. has an antipyretic effect on the root bark, and its decoction is given to rabbits with fever (temperate method) and can reduce body temperature. Intravenous injection of another fresh white D. Albus var. Caucasicus extract can shorten the clotting time.
6. Other effects: Mixtures of diterpenoid, verdividine, and cliffsine can reduce the effects of adrenaline on the seminal vesicles of guinea pigs. Yinchun can paralyze muscles and can cause a progressive decrease in blood pressure in mammals due to cardiac involvement. Yinchun can increase the tension of striated muscle and enhance the excitability of spinal cord reflex. The pharmacological activity of trigonelline is weak, but in early years it was reported that neuromuscular samples could reduce the time value of nerves, while the time value of muscles first decreased and then increased. In addition, trigonelline has a certain anti-cancer effect, 12.5mg/kg can extend the life of P388 leukemia mice by 31%.
7. Drug (poison) science: The mice LD50 alkaloids, pepper alkali, Yin Yin base intraperitoneal injection of 150-250mg/kg; trigonelline in rats subcutaneous injection of LD50 5.0g/kg.
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