Release date: 2010-03-18
A collaboration between scientists at the University of Montreal in Canada and the Florida Institute of Immunology and Gene Therapy found that the combination of membrane protein PD-1 and the cell-derived factor IL-10 affects the normal function of CD4 T cells in AIDS patients. , which leads to the damage of the patient's immune system and accelerates the development of the patient's condition. Experts believe that the new findings will play an important role in the research and development of new drugs for the treatment of AIDS. Related articles were published in the recently published journal Nature Medicine.
The main researcher of the joint research project, Professor Rafik Sikari of the University of Montreal, said that their research found that the bacterial product released from the intestine during the human infection of HIV caused the membrane protein PD-1 to be up-regulated. This led to an increase in the production of the cell-derived factor IL-10, which is the culprit in destroying the immune system. Sikari said that this is the first time in the world that the two molecules PD-1 and IL-10 can work together to affect the normal function of CD4T cells in AIDS patients, thereby damaging the immune system and accelerating the disease.
Professor Sikari believes that it can be seen from the results of the study that it is very important to block the interaction between IL-10 and PD-1 molecules in order to restore the immune response of AIDS patients. This is the direction of developing drugs to help patients rebuild immune functions that are destroyed by HIV. Meditech Medical Network
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