Pharmacological effects
Zhimu products
1. Anti-pathogenic microorganisms in vitro experiments show that: Zhimu decoction has a strong inhibitory effect on staphylococcus, typhoid bacillus, against Shigella, paratyphoid bacillus, E. coli, Bacillus subtilis, Vibrio cholerae, Proteus, diphtheria bacilli, Streptococcus pneumoniae, β-hemolytic streptococcus, Candida albicans, etc. also have different degrees of inhibition. The crude crystals obtained from Zhimu Ethanol Extract, Ether Extract and Ether Extract plus Acetone have a strong inhibitory effect on the H37RV human Mycobacterium tuberculosis subsp. Antibacterial bacilli have the highest antibacterial titer. The saponins have no effect. However, it has been reported that a water-soluble saponin from Anemarrhena asphodeloides has a strong inhibitory effect on Mycobacterium tuberculosis, especially against Candida albicans, while another flavonoid crystal has an inhibitory effect on Mycobacterium tuberculosis. Treatment of guinea pig experimental tuberculosis with 3% timmotherapy baits for 3 to 4 months has good curative effect; it can also reduce lung lesions in experimental tuberculosis mice, but the mortality rate does not decrease; if the drug concentration is increased to At 5%, the pulmonary tuberculosis index (reflecting the general lesions of the lungs) is close to isoniazid, but the mortality rate is higher than that of the control group, which may be due to the greater toxicity of the drug itself.
In addition, 8% to 20% concentration of Zhimu decoction on the Sabourin's medium also has antibacterial effect against common pathogenic dermatophytes such as Trichophytonchus xylophilus, Trichophyton mentachae, Trichophyton mentagrophytes. There are also reports that timosaponin has a snail control effect.
2. Antipyretic effect Anemarrhena extract 4g/kg subcutaneous injection, can prevent and treat E. coli induced rabbit hyperthermia, and lasting effect. The saponins contained in rhizomes of Rhizoma anemarrhenae significantly reduce the oxygen consumption rate caused by thyroxine and inhibit the activity of Na+, K+-ATPase.
3. Effects on the effects of corticosteroids Rats taking nourishing yin and reducing anger Herbal medicine Zhimu Gancao Decoction or its single herb can both increase the concentration of plasma cortisol that is inhibited by dexamethasone and prevent adrenal atrophy. Rehmannia root licorice soup and hormones taken at the same time, can reduce the side effects of hormones. Zhimu saponins, similar to Zhimu decoction, can significantly reduce brain β-receptor RT in mice with high thyroid hormone status, but has no effect on affinity and can significantly improve the state of mice. The weight loss.
4. Effects on Blood Glucose After normal rabbits were injected with Zhimu dry extract (6g/kg), there was no effect on blood glucose, and alcohol extracts could cause temporary elevation of blood glucose. Rhizoma Anemarrhena extract can reduce blood glucose levels in normal rabbits, especially in oxytetracycline-induced diabetic rabbits. Baihujia Ginseng Decoction (Anemarrhena, Panax ginseng, licorice) extract 0.5 ~ 1g/kg intraperitoneal injection, the experimental diabetic mice also have a role in lowering blood glucose, 6 hours after administration decreased 120mg%. In normal rats, anemarrhena can not increase the oxidation of glucose, although it can promote the glucose uptake of diaphragm and adipose tissue, the content of glycogen in the diaphragm increases slightly, but the content of hepatic glycogen decreases. For the experimental (alloxan) diabetic mice, 0.15 g/kg aqueous extract of Rhizoma Anemarrhenae was injected intraperitoneally. The 5-hour blood glucose decreased by 200 mg%, and the urinary ketone body decreased.
5. Other effects of Anemarrhena extract had no significant effect on the isolated uterus of pregnant rabbits. The β-sitosterol obtained from the rhizome of Xiling Rhizoma Anemarrhenae has good curative effect and no side effect in the treatment of squamous cell carcinoma and cervical carcinoma. The antitumor mechanism of timosaponin is related to its strong inhibitory effect on the cell membrane pump. The niacin contained in Anemarrhenae has the effect of maintaining skin and nerve health and promoting digestive function. The mango tincture obtained from the leaves of Anemarrhena asphodeloides has obvious choleretic effects; it also inhibits platelet aggregation.
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