Release date: 2015-01-21
The team of the Institute of Microbiology and Epidemiology of the Academy of Military Medical Sciences, Zhou Yusen team, together with the Zenglin team of the Experimental Animal Center of the Institute, the Li Yan team of the Institute of Basic Medicine, the Jiang Shibo team of Shanghai Fudan University, and the team of Guo Renfeng, the chief scientist of Inflarx Gmbh, Germany, conducted research and found that people were infected. A new pathogenic mechanism of H7N9 avian influenza virus. By infecting the virus, the virus can cause excessive activation of the immune protein molecule, the complement system, which causes acute lung injury. Based on this finding, they adopted a new therapeutic strategy to regulate the molecular expression of complement by an antibody against anaphylatoxin C5a, which confirmed that the "inflammatory factor storm" can be greatly reduced, and the pathological damage of lung tissue can be significantly reduced, thereby being effective. Treats severe pneumonia caused by viral infections. The results were published in the latest issue of the Journal of Clinical Infectious Diseases, an authoritative academic journal in the field of international infectious disease research. Dr. Sun Shihui and Dr. Zhao Guangyu, the first authors of the paper, played an important role in the research.
Complement is a group of thermolabile enzyme-active proteins present in serum and tissue fluids. As early as the end of the 19th century, human scientists confirmed that the blood contains a heat-labile ingredient that can help and supplement specific antibodies, mediating immune lysis and hemolysis, so it is called complement. Complement is a multi-molecular system consisting of more than 30 soluble proteins, membrane-bound proteins and complement receptors, so it is called the complement system. Complement plays an important role in immune and physiological functions in the human body. When certain factors cause abnormal expression, it causes disease damage.
The research by Zhou Yusen's team showed that complement-mediated immunopathological damage played a very important "catalyst" role in the pathogenesis of severe pneumonia. Therefore, the use of immunosuppressive strategies targeting inhibition of complement can effectively treat severe pneumonia caused by viral infection, opening up a new way to alleviate the patient's condition and save the patient's life.
Source: China Science and Technology Network - Technology Daily
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