Release date: 2015-01-20
The US "Science" magazine recently published a paper on a new cancer-targeted treatment that may curb the growth of osteosarcoma, brain tumors and certain pancreatic tumors, but this method has yet to be verified through clinical research. .
This study aims to inhibit the growth of several invasive tumors by blocking the signaling pathways that cancer cells use to maintain their proliferative capacity. The discovery of genetic markers that predict cancer cell weakness and the development of new drugs for these weaknesses is a focus of current cancer research.
Zou Li, the co-author of the paper and the deputy director of the Cancer Center of the Massachusetts General Hospital, said that if normal cells continue to divide, their chromosome ends will become shorter and shorter, eventually dying. Cancer cells, by repairing the ends of chromosomes, avoid death. There are two pathways: telomerase and another telomere elongation replacement mechanism (ALT). About 85% of all cancers rely on telomerase to extend chromosome ends, and the remaining 15% rely on ALT.
Zou Li et al. studied cancer cells that depend on ALT and found that phosphorylation kinase ATR is a major regulator of ALT. He said: "If we use drugs to suppress ATR in cancer cells that depend on ALT, these cancer cells will be killed."
According to Zou Li, several invasive tumors mainly rely on ALT to survive, including osteosarcoma, brain tumors and neuroendocrine pancreatic tumors. Therefore, ATR inhibitors "may be particularly effective against these types of cancer."
Zou Li said: "We are conducting animal experiments. In the near future, we will conduct clinical trials with the clinical department. This is the first targeted treatment for cancers that rely on ALT to survive, which may prolong the lives of cancer patients and even cure them. Some patients, but this treatment needs to be further verified by experiments."
Source: China Science and Technology Network
Kn95 3D Mask,Kn95 Face Mask,Kn95 Filters Mask,Kn95 Cup Face Mask
Jiangmen anjian biotechnology co. LTD , https://www.jmanjianmask.com