Angelica on nervous system inhibition

Inhibition of the nervous system

Angelica has long been reported to have an inhibitory effect on the central nervous system. Japanese scholars reported that the volatile oil of An-gelica acutiloba Kitagalia has sedative, hypnotic, analgesic and anesthetic effects.

1. Effect of Ligustilide on Spontaneous Activity of Mice

2.8% Tween 80 to form an emulsion for use. One mouse was placed in the activity box at a time, and YSD-4 type pharmacology and physiological experiment was used to record the number of mouse activities 10 minutes before and 10-20 minutes after administration, and it was stable with known drugs. Amphetamine comparison, the results show that: 1% ligustilide 98mg/kg can significantly reduce the spontaneous activity of mice, compared with the control group very significantly decreased mouse activity was significantly reduced, but also observed that mice are extremely quiet, but not sleep, Still responds to slight irritations. This phenomenon is similar to stability. Angelica also contains succinic acid and ferulic acid, succinic acid is reported to have a sedative effect, while ferulic acid sodium can reduce the number of mouse activities, but compared with the control group, the difference is not significant.

2. Effect of ligustilide on stimulant effect of ketamine

Animals and experimental methods are the same as above. Record 0-10 minutes before and after administration and 10-20 minutes of mouse activity. The results showed that: 0.5% ketamine 40mg/kg irritability in mice, endless crawling in the activity box, the number of activities significantly increased than before administration. Simultaneous use of ligustilide at 98 mg/kg and 196 mg/kg could significantly reduce the above-mentioned response caused by ketamine, and its efficacy was positively correlated with the dose. There was no central inhibition of sleep and anesthesia that aggravated ketamine.

3. Effect of ligustilide on irritability induced by electrical stimulation in mice

The mice were male and female, and the same gender was used as a pair. The multimeter was used to connect with conductive copper mesh. The stimulation was continuous. The pulse output was 1 second per second. The duration of the stimulation was 1/8 second, and the output AC voltage was 92.8 volts. 10 minutes before and 10 minutes after administration was recorded, one pair of mice developed an irritated reaction (the time when the mice were erected, the two forelimbs were off the ground, and they were licking and biting each other). RESULTS: Ten minutes after administration of 3% ligustilide at 294 mg/kg, the irritated reaction time of mice induced by electrical stimulation was prolonged significantly. The difference was very significant compared with the control group. The effect was similar to that of chlorpromazine.

4. Synergistic effect of ligustilide and pentobarbital

When the temperature is maintained at 25-28°C, ligustilide at 98 mg/kg and 196 mg/kg can significantly shorten the sleep time of mice using pentobarbital sodium 35 mg/kg (indicated by the disappearance of righting reflexes as an indicator of falling asleep). Extend the maintenance time of sleep (in order to correct it and reverse it and infuse it with two steps).

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