Tian Jihuang - pharmacological effects

Pharmacological effects

【Diuresis effect: Anesthetized dog iv Tianji yellow infusion 0.1g/kg or Tianjihuang total alkaloid 6.6mg/kg, normal rat ig1g/kg, and normal human po Tianji powder 10-30g, have Significant and long-lasting diuresis, urinary chloride excretion also increased significantly. When the inulin isolated from Tian Ji Huang was given to the rats, po or ip, the diuretic effect was inhibited.

[Effects on the nervous system]: Tianjihuangine has similar effects on the nervous system as nicotinamide, but its intensity is only 1/5-1/20 of that of nicotine. It exerts on the vegetative ganglion, adrenal medulla, and medulla (especially in the vomiting center), nerve-muscle joints, and chemoreceptors of the carotid body and aortic body all have an excitatory and post-inhibitory effect.

【Inhibitory effect on the central nervous system】: This product contains succinic acid in mice, rats, guinea pigs, rabbits, cats and dogs ip administration can protect animals against hyperbaric oxygen, electrical shock and hearing convulsions. The hot plate method has analgesic effect and has a synergistic effect with pentobarbital sodium.

Calm and reduce body temperature.

田基黄

Respiratory stimulant: Tian Jihuang decoction and its alkaloid formulation iv have significant respiratory stimulatory effects on anesthetized dogs. Its effect is enhanced and prolonged with increasing dose. Excessive doses can cause respiratory paralysis and death. After the sinus nerve was removed or the carotid body was removed, Tianjihuang preparations were injected again, and there was no obvious respiratory stimulant effect. It was shown that the mechanism of action is mainly through stimulating carotid body chemoreceptors and reflecting excitable respiratory centers. Tinchifloxacin has a good stimulatory effect on morphine-induced respiratory depression, and is worse for urethane and chloral hydrate. Tian Ji Huang Jin inhaled, there is expansion of the bronchial effect, against the pilocarpine and acetylcholine-induced tracheal contraction.

[Effects on the cardiovascular system]: Tianji yellow infusion iv has a significant and long-lasting antihypertensive effect on anesthetized dogs. Such as duodenal administration requires 10-20 times the amount of intravenous administration to have an effect. It has also been reported that a small amount of decoction iv has a short-term boosting effect; at larger doses, it has a longer-lasting antihypertensive effect. Tianjihuang alkaloids have excitatory effects on isolated rabbit hearts and frog hearts, which results in increased contractile force and increased amplitude. At high concentrations, temporary excitation occurs, followed by inhibition, and finally conduction block and arrest. Tian Ji Huang Huang im, in the breath of excitement at the same time, the heart rate slows, blood pressure increased; high doses, the heart rate increased, blood pressure decreased significantly, and finally to the heart paralysis.

【Cholera effect】: Canine iv Tian Jihuang boiled alcohol precipitation formula 1g (crude drug)/kg, bile flow rate increased by 2 times than before

Tian Jihuang

On the other hand, the effect peaked after 50 minutes of administration, but the concentrations of bile solids, cholate, and bilirubin all decreased.

[anti-venom effect]: Tian Jihuang preparation, and isolated from the sodium succinate, sodium fumarate, sodium paraben, respectively, 30 minutes before the injection of snake venom po, or at the same time as the injection of snake venom sc drugs, or with sodium succinate, The composition of sodium fumarate and sodium acetate is 30 minutes to 4 hours before the injection of snake venom, which has a higher protective effect on mice injected with the smallest total lethal dose of cobra venom, and the protection rate is 59.1-93.1%. However, if it is administered 25 minutes after the injection of snake venom, there is no protection.

[Other effects]:

1.1. Anti-ulcer effect: This product contains succinic acid 50mg/kg, can resist gastric ulcer caused by pylorus ligation in rats, is due to inhibition of gastric secretion and expansion of gastric muscle and antiulcer effect. Cats and dogs impetramine have an antiemetic effect.

1.2. Laxative effect: Tian Ji Huang decoction po has laxative effect, and can suppress appetite.

1.3. Antimicrobial effect: In vitro test, Tianjihuang decoction has obvious inhibitory effect on common pathogenic fungi. Staphylococcus aureus and E. coli also have inhibitory effects.


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